Xiaoming Zhou

PhD

Department of Primary Appointment:
School of Medicine
Medicine
Title
Research Associate Professor
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Tourniquet- and sepsis-induced acute kidney injury
Sickle cell disease-induced chronic kidney injury, Tourniquet- and sepsis-induced acute lung injury
Email
xiaoming.zhou@usuhs.edu
Office Phone
(301) 295-9604

Education

BM, Nanjing University of Chinese Medicine and Pharmacy, Nanjing, China, 1978-1982.
MS, China Pharmaceutical University, Nanjing, China, 1984-1987.
PhD, University of Florida, Gainesville, FL, 1988-1992.
Post-doctoral fellowship, The Johns Hopkins University, Baltimore, MD, 1992-1996.

Biography

Dr. Zhou’s laboratory has focused on how to alleviate lower limb ischemia/reperfusion- and sepsis-induced acute kidney injury (AKI), using cell culture and mice as models. Currently, there is no specific treatment for AKI. As a result, AKI significantly increases morbidity and mortality of patients and financial burden to the society. Tourniquet is the first aid to control limb hemorrhage in military operations and civilian settings. However, prolonged application of tourniquets can induce lower ischemia/reperfusion injury, leading to “sterile” systemic inflammation and multi-organ injury, including AKI, and multi-organ failure. Trauma can lead to sepsis, non-sterile systemic inflammation, resulting in acute kidney and other organ injuries. A majority of forms of AKI shares microcirculation dysregulation and hypoxia in the kidney. In light of this, Dr. Zhou's laboratory is studying whether reducing oxygen demand such as by inhibiting sodium absorption in the kidney can ameliorate tourniquet- and sepsis-induced AKI.

Career Highlights: Positions, Projects, Deployements, Awards and Additional Publications

Packialakshmi B, Stewart IJ, Burmeister DM, Chung KK, Zhou X. Large animal models for translational research in acute kidney injury. Ren Fail. 2020 Nov;42(1):1042-1058. doi: 10.1080/0886022X.2020.1830108.PMID: 33043785.

Hira S, Packialakshmi B, Tang E, Zhou X. Dexamethasone up-regulates mitochondrial Tom20, Tom70 and MnSOD through SGK1 in the kidney cells. J Physiol Biochem. 2021 Feb;77(1):1-11. doi: 10.1007/s13105-020-00773-x. Epub 2020 Nov 17.PMID: 33201408.

Packialakshmi B, Stewart IJ, Burmeister DM, Feng Y, McDaniel DP, Chung KK, Zhou X. Tourniquet-induced lower limb ischemia/reperfusion reduces mitochondrial function by decreasing mitochondrial biogenesis in acute kidney injury in mice. Physiol Rep. 2022 Feb;10(3):e15181. doi: 10.14814/phy2.15181.PMID: 35146957.

Packialakshmi B, Hira S, Lung K, Zhang AH, Halterman J, Feng Y, Scott DW, Lees JR, Zhou X. NFAT5 contributes to the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and decrease of T regulatory cells in female mice. Cell Immunol. 2022 May;375:104515. doi: 10.1016/j.cellimm.2022.104515. Epub 2022 Apr 6.PMID: 35417812.

Chomiak AA, Lowe CC, Guo Y, McDaniel D, Pan H, Zhou X, Zhou Q, Doughty ML, Feng Y. Nde1 is required for heterochromatin compaction and stability in neocortical neurons. iScience. 2022 May 5;25(6):104354. doi: 10.1016/j.isci.2022.104354. eCollection 2022 Jun 17.PMID: 35601919.

Zhou X. A step forward toward establishing a novel preclinical porcine model to study ischemia/reperfusion-induced acute and chronic kidney injures. Translational Andrology and Urology, editorial, 2022 May;11(5):575-577. doi: 10.21037/tau-22-176. PMID: 35693710.

Guo Y, Chomiak AA, Hong Y, Lowe CC, Kopsidas CA, Chan WC, Andrade J, Pan H, Zhou X, Monuki ES, Feng Y. Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration. iScience. 2022 Jun 3;25(7):104519. doi: 10.1016/j.isci.2022.104519. eCollection 2022 Jul 15.PMID: 35754718.

Packialakshmi B, Hira S, Feng Y, Scott DW, Lees JR, Zhou X. High K+ intake alleviates experimental autoimmune encephalomyelitis (EAE) and increases T regulatory cells. Cell Immunol. 2022 Dec; 382:104637. doi: 10.1016/j.cellimm.2022.104637. Epub 2022 Nov 3. PMID: 36343517.

Zhou X. Reducing Oxygen Demand to Alleviate Acute Kidney Injury. Front Biosci (Landmark Ed). 2023 Mar 28;28(3):62. doi: 10.31083/j.fbl2803062. PMID: 37005768.

Packialakshmi B, Burmeister DM, Anderson AA, Morgan J, Cannon G, Kiang JG, Feng Y, Lee S, Stewart IJ, Zhou X. A Clinically-relevant Mouse Model that Displays Hemorrhage Exacerbates Tourniquet-induced Acute Kidney Injury. Front Physiol. 2023 Nov 8:14:1240352. doi: 10.3389/fphys.2023.1240352. eCollection 2023. PMID: 38028812.

Representative Bibliography

Packialakshmi B, Stewart IJ, Burmeister DM, Chung KK, Zhou X. Large animal models for translational research in acute kidney injury. Ren Fail. 2020 Nov;42(1):1042-1058. doi: 10.1080/0886022X.2020.1830108.PMID: 33043785.

Packialakshmi B, Stewart IJ, Burmeister DM, Feng Y, McDaniel DP, Chung KK, Zhou X. Tourniquet-induced lower limb ischemia/reperfusion reduces mitochondrial function by decreasing mitochondrial biogenesis in acute kidney injury in mice. Physiol Rep. 2022 Feb;10(3):e15181. doi: 10.14814/phy2.15181.PMID: 35146957.

https://www.ncbi.nlm.nih.gov/myncbi/1pWwy97o6hwQo/bibliography/public/

Packialakshmi B, Limerick E, Ackerman HC, Lin X, Nekhai S, Oliver III JD, Stewart IJ, Knepper MA, Fitzhugh C, Zhou X. Proteomic analyses of urinary exosomes identify novel potential biomarkers for early diagnosis of sickle cell nephropathy, a sex-based study. Front Physiol. DOI: 10.3389/fphys.2024.1300667.