Juliann Kiang M.A., Ph.D.

Education

Postdoctoral, University of California, Berkeley, CA 1984-1988
Ph.D. University of California, Berkeley, CA, 1983
M.A. University of Nebraska, Omaha, NE, 1977
B.S. FuJen Catholic University, Taipei, Taiwan, ROC, 1975

Biography

Dr. Juliann Kiang is a principal investigator at Armed Forces Radiobiology Research Institute (AFRRI). She is Adjunct Professor in Department of Pharmacology and Molecular Therapeutics and in Department of Medicine, School of Medicine, Uniformed Services University of the Health Sciences (USU).

Dr. Kiang serves in editorial boards of several scientific journals, NIH and VA study sections, and USU committees. She worked in Water Reed Army Institute of Research from 1989 to 2006 before joining AFRRI.

Dr. Kiang is involved in studies showing corticotrophin-releasing factor and heat shock proteins are capable of protecting against edema/inflammation and hypoxia injury, respectively. She demonstrates that overexpression of inducible form of heat shock protein 70 kDa induced by sublethal heat stress, chemical stimulation, or the gene transfer produces thermotolerance and cross-tolerance that may be related to an inhibition of changes in intracellular calcium concentrations and expression of stress-related genes and proteins such as inducible nitric oxide synthase and p38-MAPK. She has found 17-DMAG, mesenchymal stem cells, G-CSF, ghrelin, or ciprofloxacin that can make cells endure much better under circumstances of low oxygen, a way to treat heat stroke, ischemia, hemorrhage, cancer, heart attack, stroke, or ionizing radiation injury.

Dr. Kiang had made five major contributions in her research career (journal references to work are noted).

Dr. Kiang is the first to demonstrate that treatment with corticotrophin-releasing factor (CRF) inhibits neurogenic and thermally-induced protein extravasation in rats (9-14). She also found that urotensin I and sauvagine (members of the CRF superfamily) possess the same properties as CRF but with greater potency (15). She holds a patent resulting from this work. She has provided evidence that CRF and its analogs increase intracellular Ca2+ concentrations in vitro (33, 36, 50), which are correlated with capacity of these neuropeptides to inhibit thermally-induced edema (50). CRF exerts its action on CRF type 2 receptors to activate enzymes such as tyrosine kinases, phospholipase 1 and 2 to lead to a result of increases in intracellular Ca2+ concentrations (56). A patent is resulted.

Dr. Kiang’s second major contribution is that she performed extensive research to establish the effect of heat shock on components of signal transduction pathways, such as H+, Ca2+, Na+, cAMP, inositol 1,4,5-trisphosphate, and heat shock proteins in cultured cells. Her findings in this area are wide-ranging and have extended knowledge in the heat shock field (18, 19, 22, 25, 29, 40-42, 44, 46-48, 51-55, 57, 58, 60-62). Her findings provide insight to unfold the mechanisms of tolerance and cross-tolerance (64, 67). Heat shock protein 70 kDa plays a very important role in cell survival – a fine-line before occurrence of apoptosis.

Dr. Kiang’s third major contribution is that she has shown heat shock protein 70 kDa (HSP-70i) can protect the rat ileum from the ischemia/reperfusion injury (37, 66), ricin injury (47), during ileitis (57), and the mouse jejunum, lung, heart, and kidney from the hemorrhagic shock (70). She has also shown that down-regulation of inducible nitric oxide synthase inhibits the activity of caspase-3, an apoptotic protease, and overexpression of HSP-70i prevents ATP loss resulted from hemorrhage (78, 87, 91, 99, 104) or radiation-injury (106-108, 110-114). The work has resulted in a provisional patent.

Dr. Kiang’s fourth major contribution is that she has characterized radiation combined injury (110, 111, 115, 120) shown that ciprofloxacin (122, 126-128, 134), ghrelin (130, 146), and bone marrow mesenchymal stem cells (132, 140) can combat radiation injury combined with skin-wound injury. The research work is ongoing. Meanwhile, she established a new combined injury model of radiation with hemorrhage (135, 138, 142, 145) that brought her the 2016 AFRRI Research Award.

Dr. Kiang fifth major contribution is that she has characterized radiation sensitivities between male and female mice and the underlying mechanisms on the sex-disparity (160). She has shown that female mice were less sensitive to radiation than male mice due to less production of miR-34a, C3, IL-18 and MAPK activation but greater increase in G-CSF (160). The work has resulted in The 2022 AFRRI Radiobiology Research as Senior Principal Investigator.

Bibliography

Peer-reviewed publications (164)
1. Kiang JG, Dewey WL, and Wei ET. Tolerance to morphine bradycardia in the rat. J. Pharmacol Exp. Ther. 226:187 192, 1983.
2. Kiang JG and Wei ET. Inhibition of an opiate-induced vagal reflex in rats by naloxone, SMS 201 995 and ICI 154, 129. Regulatory Peptides 6:255 262, 1983.
3. Dashwood MR, Kiang JG, and Wei ET. An etorphine-evoked reflex in rats is inhibited by naloxone, N-methylnaloxone, and SMS 201 995. Arch. Int. Pharmacodyn. Ther. 266:77 82, 1983.
4. Kiang JG and Wei ET. Sensitivity to morphine-evoked bradycardia in rats is modified by dynorphin (1 13), (Leu)enkephalin and (Met)enkephalin. J. Pharmacol. Exp. Ther. 229:469 473, 1984.
5. Kiang JG and Wei ET. Peripheral opioid receptors influencing heart rate in rats: evidence for endogenous tolerance. Regulatory Peptides 8:297 303, 1984.
6. Tang J, Webber RJ, Chang D, Chang JK, Kiang JG, and Wei ET. Depressor and natriuretic activities of several atrial peptides. Regulatory Peptides 9:543 549, 1984.
7. Wei ET and Kiang JG. Peripheral opioid receptors influencing heart rate in rats. In: Opioid Peptides in the Periphery. (Eds, F. Fraioli, A. Isidori and M. Mazzetti) Developments in Neuroscience 18:95 101, 1984, Amsterdam, Elsevier.
8. Kiang JG and Wei ET. CRF-evoked bradycardia in urethane-anesthetized rats is blocked by naloxone. Peptides 6:409 413, 1985.
9. Kiang JG and Wei ET. CRF: an inhibitor of neurogenic plasma extravasation produced by saphenous nerve stimulation. Eur. J. Pharmacol. 114:111 112, 1985.
10. Wei ET, Kiang JG, Buchan P, and Smith T. Corticotropin-releasing factor (CRF) inhibits neurogenic plasma extravasation in the rat paw. J. Pharmacol. Exp. Ther. 238:783 787, 1986.
11. Kiang JG and Wei ET. Corticotropin-releasing factor (CRF) inhibits thermal injury. J. Pharmacol. Exp. Ther. 243:517- 520, 1987.
12. Wei ET and Kiang JG. Inhibition of protein exudation from the trachea by corticotropin-releasing factor. Eur. J. Pharmacol. 140:63-67, 1987.
13. Wei ET, Kiang JG, and Tien JQ. Anti-inflammatory activity of corticotropin-releasing factor: I. Efficacy studies. Proc. West. Pharmacol. Soc. 30:59 62, 1987.
14. Kiang JG, Poree L, and Wei ET. Anti-inflammatory activity of corticotropin-releasing factor: II. Mechanisms of action. Proc. West. Pharmacol. Soc. 30:63 65, 1987.
15. Wei ET and Kiang JG. Peptides of the corticoliberin superfamily attenuate thermal and neurogenic inflammation in rat paw skin. Eur. J. Pharmacol. 168:81 86, 1989.
16. Kiang JG and Colden-Stanfield M. Morphine induces an intracellular alkalinization in bovine aortic endothelial cells (BAECs), In: International Narcotic Research Conference (INRC) '89. (Eds. R. Quirion, K. Jhamandas and C. Gianoulakis) Alan Liss Press, N.Y., Prog. Clin. Biol. Res. 328:137 140, 1989.
17. Wei ET, Wong JC, and Kiang JG. Decreased inflammatory responsiveness of hypophysectomized rats to heat is reversed by a CRF antagonist. Regulatory Peptides 27:317 323, 1990.
18. Kiang JG, McKinney LC, and Gallin EK. Heat induces an intracellular acidification in human A 431 cells: role of Na+/H+ exchanger and metabolism. Am. J. Physiol., 259(Cell Physiol. 28):C727-C737, 1990.
19. Kiang JG, Wu YY, and Lin M. Hyperthermia elevates cAMP levels in human epidermoid A 431 cells. Biochem. J. 276:683 689, 1991.
20. Kiang JG. Effect of intracellular pH on cytosolic free [Ca2+]i in A-431 cells. Eur. J. Pharmacol. 207(Molecular Pharmacol. Section):287-296, 1991.
21. Lin W-W, Kiang JG, and Chuang D-M. Pharmacological characterization of endothelin-stimulated phosphoinositides breakdown and cytosolic Ca2+ rise in C6 rat glioma cells. J. Neurosci., 12:1077 1085, 1992.
22. Kiang JG, Koenig ML, and Smallridge RC. Heat shock increases cytosolic free Ca2+ concentration via the Na+/Ca2+ exchange in human epidermoid A 431 cells. Am. J. Physiol. 263(Cell Physiol. 32):C30-38, 1992.
23. Smallridge RC, Gist ID, and Kiang JG. Na+-H+ antiport and monensin effects on cytosolic pH and iodide transport in FRTL 5 rat thyroid cells. Am. J. Physiol. 262(Endocrinol. Metab.) 25:E834-E839, 1992.
24. Smallridge RC, Kiang JG, Gist ID, Fein HG, and Galloway R. U 72133 inhibits TRH-induced activities in GH3 cells. Endocrinol. 131:1883 1888, 1992.
25. Kiang JG and McClain DE. Effect of heat shock, Ca2+, and cAMP on inositol 1,4,5-trisphosphate in human epidermoid A 431 cells. Am. J. Physiol. 264 (Cell Physiol. 33):C1561-C1569, 1993.
26. Aloj SM, Liguoro D, Kiang JG, and Smallridge RC. Purinergic (P2) receptor -operated calcium entry into rat thyroid cells. Biophy. Biochim. Res. Comm. 195:1-7, 1993.
27. Kiang JG. Corticotropin-releasing factor increases cytosolic free calcium via receptor-mediated Ca2+ channels. Eur. J. Pharmacol. (Molecular Pharmacol. Section) 267:135-142, 1994.
28. Kiang JG and Smallridge RC. Sodium cyanide increases cytosolic free calcium: Evidence of activation of the reversed mode of Na+/Ca2+ exchanger and Ca2+ mobilization from inositol trisphosphate-insensitive pools. Toxicol. Appl. Pharmacol., 127:173-181, 1994.
29. Kiang JG, Carr FE, Burns MR, and McClain DE. HSP-72 synthesis is promoted by increase in [Ca2+]i or activation of G proteins but not pHi or cAMP. Am. J. Physiol. 267 (Cell Physiol. 36):C104-C114, 1994.
30. Tang T, Kiang JG, and Cox BM. Opioids acting through delta-receptors increase the intracellular free calcium concentration in the dorsal root ganglion neuroblastoma hybrid ND8-47 cells. J. Pharmacol. Exptl. Ther., 270:40-46, 1994.
31. Wang X, Kiang JG, and Smallridge RC. U-73122 inhibits increases in inositol trisphosphates and cytosolic free [Ca2+] induced by TSH in FRTL-5 cells. Bioph. Biochim. Acta, 1223:101-106, 1994.
32. Poola I and Kiang JG. The estrogen inducible transferrin receptor-like membrane glycoprotein is related to stress regulated proteins. J. Biol. Chem. 269:1-8, 1994.
33. Kiang JG, Wang XD, and McClain DE. Corticotropin-releasing factor increases protein kinase C activity by elevating isoforms  and  at the membrane. Chin J. Physiol. 37:105-110, 1994.
34. Wang XD, Kiang JG, and Smallridge RC. Identification of protein kinase C and its multiple isoforms in Frtl-5 thyroid cells. Thyroid 5:137-140, 1995.
35. Tang T, Kiang JG, Cote T, and Cox BM. Opioid-induced increase [Ca2+]i in ND8-47 neuroblastoma X DRG hybrid cells is mediated through G protein-coupled delta opioid receptors and desensitized by chronic exposure to opioid. J. Neurochem. 65:1612-1621, 1995.
36. Kiang JG. Mystixin-7 and Mystixin-11 increase [Ca2+]i and inositol trisphosphates in human A-431 cells. Eur. J. Pharmacol. (Mol. Pharmacol. Section) 291:107-113, 1995.
37. Stojadinovic A, Kiang JG, Smallridge RC, Galloway RL, and Shea-Donahue T. Heat shock protein 72 kD induction protects rat intestinal mucosa from ischemia/reperfusion injury. Gastroenterol. 109:505-515, 1995.
38. Tang T, Kiang JG, Cote T, and Cox BM. Antisense oligodeoxynucleotide to Gái2 protein á-subunit sequence inhibits an opioid-induced increase in intracellular free calcium in ND8-47 neuroblastoma x DRG hybrid cells. Mol. Pharmacol. 48:189-193, 1995.
39. Ding XZ, Smallridge RC, Galloway RJ, and Kiang JG. Rapid assay of HSF1 and HSF2 gene expression by reverse transcriptase PCR. Mol. Cell Biochem. 158: 48-51, 1996.
40. Ding XZ, Smallridge RC, Galloway RJ, and Kiang JG. Increases in HSF1 translocation and synthesis in human epidermoid A-431 cells: role of protein kinase C and [Ca2+]i. J. Investig. Med. 44:144-153, 1996.
41. Kiang JG, Ding XZ, and McClain DE. Thermotolerance attenuates heat-induced increases in [Ca2+]i and HSP-72 synthesis but not heat-induced intracellular acidification in human A-431 cells. J. Investig. Med. 44:189-192, 1996.
42. Kiang JG, Wang XD, Ding XZ, Gist I, and Smallridge RC. Heat shock inhibits the hypoxia-induced effects on iodide uptake and signal transduction and enhances cell survival in rat thyroid FRTL-5 cells. Thyroid, 6:475-483, 1996.
43. Wang XD, Kiang JG, Atwa MA, and Smallridge RC. Evidence for the involvement of protein kinase C isoforms in á-1 adrenergic activation of phospholipase A2 in Frtl-5 thyroid cells, J. Investig. Med. 44:566-574, 1996.
44. Kiang JG and Koenig ML. Characterization of intracellular calcium pools in thermotolerant and their desensitization in thermotolerant cells. J. Investig. Med. 44:352-361, 1996.
45. Kiang JG and Tsokos GC. Signal transduction and heat shock protein expression. J. Biomed. Sci. 3:379-388, 1996.
46. Ding XZ, Tsokos GC, Smallridge RC, and Kiang JG. Heat shock gene expression in HSP-70 and HSF1 gene-transfected human epidermoid A-431 cells. Mol. Cell. Biochem. 167:145-152, 1997.
47. Stojadinovic A, Kiang JG, Smallridge RC, Galloway RL, and Shea-Donahue T. Induction of the heat shock response limits tissue injury during acute inflammation of the rat ileum. Critical Care Medicine 25:309-317, 1997.
48. Ding XZ, Tsokos GC, and Kiang JG. Heat shock factor 1 protein in heat shock factor 1 gene-transfected human epidermoid A-431 cells requires phosphorylation prior to inducing heat shock protein-70 production. J. Clin. Investig. 99:136-143, 1997.
49. Liossis S-N, Ding XZ, Kiang JG, and Tsokos GC. Overexpression of HSP70 offers thermoprotection but enhances the TCR/CD3- and Fas-induced apoptotic death in Jurkat T-cells. J. Immunol. 158:5668-5675, 1997.
50. Kiang JG. Corticotropin-releasing factor-like peptides increase cytosolic free calcium in human epidermoid A-431 cells. Eur. J. Pharmacol. (Molecular Pharmacology Section), 329:237-244, 1997.
51. Kiang JG, Gist ID, and Tsokos GC. 17-Estradiol-induced increases in glucose-regulated proteins protect human breast cancer T47-D cells from thermal injury. Chin. J. Physiol. 40:213-219, 1997.
52. Kiang JG, Ding XZ, and McClain DE. Overexpression of HSP-70 attenuates increases in [Ca2+]i and protects human epidermoid A-431 cells after chemical hypoxia. Toxicol. Appl. Pharmacol. 149:185-194, 1998.
53. Ding XZ, Tsokos GC, and Kiang JG. Overexpression of HSP-70 inhibits the phosphorylation of HSF1 by activating protein phosphatase and inhibiting protein kinase C activity. FASEB. J. 12:451-459, 1998.
54. Kiang JG, Gist ID, and Tsokos GC. Cytoprotection and regulation of heat shock proteins induced by heat shock in human breast cancer T47-D cells: role of [Ca2+]i and protein kinases. FASEB J. 12: 1571-1579, 1998.
55. Kiang JG and Tsokos GC. Heat shock protein 70 kD family: Molecular Biology, Biochemistry, and Physiology. Pharmacol.Ther. 80:183-201, 1998.
56. Kiang JG, Ding XZ, Gist ID, and Tsokos GC. Corticotropin-releasing factor increases phosphotyrosine of phospholipase C- at tyrosine residues via its receptor 2 in human epidermoid A-431 cells. Eur. J. Pharmacol. 363:203-210, 1998.
57. Goldhill JM, Stojadinovic A, KiangJG, Smallridge RC, and Shea-Donohue T. Hyperthermia prevents functional, histological and biochemical abnormalities induced during ileitis. Neurogastroenterol. Mot. 11:69-76, 1999.
58. Kiang JG, Gist ID, and Tsokos GC. Biochemical requirement of heat shock protein 72 kD expression in human breast cancer MCF-7 cells. Mol. Cell. Biochem.199: 179-188, 1999.
59. Wang XD, Kiang JG, Scheibel LW, and Smallridge RC. Phospholipase C activation by Na+/Ca2+ exchange is essential for monensin-induced Ca2+ influx and arachidonic release in FRTL-5 thyroid cells. J. Investig. Med., 47:388-396, 1999.
60. Kiang JG and McClain DE. N-nitro-L-arginine decreases resting cytosolic [Ca2+] and enhances heat stress-induced increase in cytosolic [Ca2+] in human colon carcinoma T84 cells. Chin. J. Physiol. 42: 153-160, 1999.
61. Smallridge RC, Gist ID, Tsokos GC, and Kiang JG. Characterization of distinct heat shock and thapsigargin-induced cytoprotective proteins in FRTL-5 cells. Thyroid, 9: 1041-1047, 1999.
62. Kiang JG, Gist ID, and Tsokos GC. Heat shock induces expression of heat shock protein 72 kD and 90 kD in human breast cancer MDA-231 cells. Mol. Cell. Biochem. 204: 169-178, 2000.
63. Kiang JC and Lu PY. Biological effects of qigong and an overview of research design and methodology. Proceedings: The Science and Spirituality of Healing, 1: 99-121, 2000.
64. Kiang JG, Kiang SC, Juang Y-T, and Tsokos GC. Nω-nitro-L-arginine inhibits the inducible heat shock protein 70 kDa via Ca2+, PKC, and PKA. Am. J. Physiol. 282:G415-G423, 2002.
65. Kiang JG, Marotta D, Wirkus M, Wirkus M, and Jonas WB. External bioenergy increases intracellular free calcium concentrations and reduces cellular response to heat stress. J. Investig. Med., 50: 38-45, 2002.
66. Fleming SD, Starnes BW, Kiang JG, Stojadinovic A, Tsokos GC, and Shea-Donohue T. Heat stress protection against mesenteric ischemia/reperfusion-induced alteration in intestinal mucosa in rats. J. Appl. Physiol. 92:2600-2607, 2002.
67. Kiang JG. Genistein inhibits herbimycin A-induced inducible heat shock protein 70 kDa. Mol Cell Biochem, 245:191-199, 2003.
68. Kiang JG, McClain DE, Warke VG, Krishnan S, and Tsokos GC. Constitutive NO synthase regulates the Na+/Ca2+ exchanger in human Jurkat T cells: role of [Ca2+]i and tyrosine phosphorylation. J. Cellular Biochem., 89:1030-1043, 2003.
69. Kiang JG, Warke VG, and Tsokos GC. NaCN-induced chemical hypoxia is associated with altered gene expression. Mol Cell Biochem 254:211-216, 2003.
70. Kiang JG, Bowman DP, Wu BW, Hampton N, Kiang AG, Zhao B, Juang Y-T, Atkins JL, and Tsokos GC. Geldanmaycin inhibits hemorrhage-induced increases in caspase-3 activity, KLF6, and iNOS expression in unresuscitated organs of mice: Role of inducible HSP-70. J Appl Phsiol 97:564-569, 2004.
71. Kiang JG, Bowman PD, Zhao B, Atkins JL, and Tsokos GC. Heat shock protein-70 inducers and iNOS inhibitors as therapeutics to ameliorate hemorrhagic shock. NATO-HFM-109-P28:1-11, 2004.
72. Fleming SD, Kiang JG, and Tsokos GC. Targeting complement in treatment of ischemia/reperfusion-induced injury. NATO-HFM-109-P24:1-13, 2004.
73. Bowman PD, Zhao B, Bynum JA, Sondeen JL, Kiang JG, Dubick MA, and Atkins JL. Application of gene expression analysis with microarrays and proteinomics to the problem of hemorrhagic shock and resuscitation. NATO-HFM-109-P29:1-15, 2004.
74. Kiang JG. Inducible heat shock protein 70 kD and inducible nitric oxide synthase in hemorrhage/resuscitation-induced injury. Cell Res 14:450-459, 2004.
75. Kiang JG, Ives JH, and Jonas WB. External bioenergy-induced increases in intracellular free calcium concentrations are mediated by the Na+/Ca2+ exchanger and L-type calcium channel. Mol Cell Biochem 271:51-59, 2005.
76. Kiang JG. Lu X, Tabaku LS, Bentley TB, Atkins JL, and Tsokos GC. Resuscitation with lactated Ringers solution limits the expression of molecular events associated with lung injury after hemorrhage. J Appl Physiol 98:550-556, 2005.
77. Krishnan S, Kiang JG, Fisher CU, Nambiar MP, Nguyen HT, Kyttaris VC, Chowdhury B, Rus V, Tsokos GC. Increased caspase-3 expression and activity contributes to reduced CD3 expression in Systemic Lupus Erythematosus T cells. J Immunol 175:3417-3423, 2005.
78. Kiang JG, Bowman DP, Lu X, Li Yansong, Ding XZ, Zhao B, Juang YT, Atkins JL, Tsokos GC. Geldanmaycin treatment prevents hemorrhage-induced ATP loss in mouse organs by overexpressing HSP-70 and activating pyruvate dehydrogenase. Am J Physiol 291:G117-G127, 2006.
79. Tsen KT, Tsen SWD, Kiang JG. Lycopene is more potent than bata carotene in the neutralization of singlet oxygen: role of energy transfer probed by ultrafast Raman spectroscopy. J Biomed Optics 11:064025 (6 pages), 2006.
80. Tsen KT, Kiang JG, Ferry DK, Morkoc H. Subpicosecond time-resolved Raman studies of LO phonons in GaN: Dependence on the injected carrier density. App Physics Lett 89:11211 (3 pages), 2006.
81. Tsen KT, Kiang JG, Ferry DK, Kochelap VA, Komirenko SM, Kim KW, Morkoc H. Subpicosecond Raman studies of electric-field-induced optical phonon instability in an In0.53Ga0.47As-based semiconductor nanostructure. J Phys: Condens Matter 18:7961-7974, 2006.
82. Kiang JG, Tsen KT. Biology of hypoxia. Chin J Physiol 49:223-233, 2006.
83. Tsen KT, Dykeman E, Sankey OF, Tsen S-WD, Lin N-T, Kiang JG. Observation of the low frequency vibrational modes of bacteriophage M13 in water by Raman spectroscopy. Virology J 3:79 (11 pages), 2006.
84. Tsen KT, Dykeman E, Sankey OF, Lin N-T, Tsen S-WD, Kiang JG. Raman scattering studies of the low frequency vibrational modes of bacteriophage M13 in water. Nanotecnology 17:5474-5479, 2006.
85. Tsen KT, Kiang JG, Ferry DK, and Morkoc H. Subpicosecond time-resolved Raman studies of field-induced transient transport in an -based p-i-n semiconductor nanostructure. App Physics Lett, 89: 262101 (3 pages), 2006.
86. Tsen KT, Kiang JG, and Ferry DK. Subpicosecond transient Raman scattering studies of field-induced electron transport in an -based p-i-n nanostructure: Direct observation of the effects of electron momentum randomization. J Phys: Condens Matter 18:L585-L592, 2006.
87. Kiang JG, Peckham RM, Duke LE, Chaudry IH, Tsokos GC. Androstenediol inhibits trauma-hemorrhage-induced increase in caspase-3 by downregulating inducible nitric oxide synthase pathway. J App Physiol 102: 933-941, 2007.
88. Tsen KT, Dykeman E, Sankey OF, Tsen S-WD, Lin N-T, Kiang JG. Probing the low frequency vibrational modes of viruses with Raman scattering -- bacteriophage M13 in water. J Biomed Optics. 12: 024009 (6 pages), 2007.
89. Tsen KT, Kiang JG, Ferry DK, Morkoc H. Subpicosecond time-resolved Raman studies of LO phonons in GaN. Proc of SPIE 6473: 64730Q-1 – 64730Q-12, 2007.
90. Tsen KT, Kiang JG, Ferry DK, Morkoc H. Studies of longitudinal optical phonons in GaN by sybpicosecond time-resolved Raman Spectroscopy. Proc of SPIE 6471: 64710X-1 – 64710X-10, 2007.
91. Kiang JG, Bowman DP, Lu X, Li Y, Wu BW, Loh HH, Tsen KT, Tsokos GC. Geldanmaycin treatment inhibits hemorrhage-induced increases in caspase-3 activity: Role of inducible nitric oxide synthase. J App Physiol 103: 1045-1055, 2007.
92. Tsen KT, Kiang JG, Ferry DK, Lu H, Scheff WJ, Lin HW, Gwo S. Direct measurements of the lifetimes of longitudinal optical phonon modes and their dynamics in InN. App Physics Lett 90: 152107 (3 pages), 2007.
93. Tsen KT, Kiang JG, Ferry DK, Lu H, Scheff WJ, Lin HW, Gwo S. Subpicosecond time-resolved Raman studies of electron-longitudinal optical phonon interactions in InN. App Physics Lett 90: 172108 (3 pages), 2007.
94. Tsen KT, Kiang JG, Ferry DK, Lu H, Schaff WJ, Lin HW, Gwo S. Electron-density dependence of longitudinal-optical phonon lifetime in InN studied by subpicosecond time-resolved Raman spectroscopy. J Phy Condens Matter 19: 236219 (8 pages), 2007.
95. Tsen KT, TsenS-W D, Chang C-L, Hung C-F, Wu T-C, Kiang JG. Inactivation of viruses by coherent excitations with low power visible femtosecond laser. Virology J 4:50 (6 pages), 2007.
96. Tsen KT, TsenS-W D, Chang C-L, Hung C-F, Wu T-C, Kiang JG. Inactivation of viruses with a very low power visible femtosecond laser. J Physics: Condens Matter 19:322102 (9 pages), 2007.
97. Tsen KT, TsenS-W D, Chang C-L, Hung C-F, Wu T-C, Kiang JG. Inactivation of viruses by laser-driven coherent excitations via impulsive stimulated Raman scattering process. J Biomed Optics 12:064030 (6 pages), 2007.
98. Tsen KT, TsenS-W D, Sankey OF, Kiang JG. Selective inactivation of microorganisms by near-IR femosecond laser pulses. J Phy Condens Matter 19: 472201 (7 pages), 2007.
99. Kiang JG, Krishnan S, Lu X, Li Y. Inhibition of inducible nitric oxide synthase protects human T cells from hypoxia-induced injury. Mol Pharmacol 73:738-747, 2008.
100. Tsen KT, Tsen SWD, Hung CF, Wu TC, Kiang JG. Selective inactivation of human immunodeficiency virus with subpicosecond near-infrared laser pulses. J Phys Condens matter 20:25220 (4 pages), 2008.
101. Atkins JL, Hammamiech R, Jett M, Gorbounov NV, Asher LV, Kiang JG. α-Defensin-4 and asymmetric dimethyl arginine (ADMA) increase in mesenteric lymph after hemorrhage in anesthetized rats. Shock 30: 411-146, 2008.
102. Tsen KT, Tsen S-W D, Chang C-L, Hung C-F, Wu T-C, Ramakrishna K, Mossman K, Kiang JG. Inactivation of viruses with a femtosecond laser via impulsive stimulated Raman scattering. In: Optical Interactions with Tissue and Cells XIX (edited by Steven L. Jacques, William P. Roach, Robert J. Thomas), Proc. of SPIE 6854: 68540N1-6854N10, 2008.
103. Tsen KT, Kiang JG, Ferry DK, Lu H, Scheff WJ, Lin HW, Gwo S. Dynamics of LO phonons in InN studied by subpicosecond time-resolved Raman spectroscopy. In: Ultrafast Phenomena in Semiconductors and Nanostructure Materials XII (edited by J.J. Song, K.T. Tsen, M. Betz and A. Elezzabi), Proc. of SPIE Vol. 6892: 689206 (12 pages), 2008.
104. Kiang JG, Kiang SC, Bowman PD. 17-DMAG inhibits hemorrhage-induced injury in small intestine and lung by inactivating caspase-3. International Proceedings of International Shock Congress K628C0171:23-27, 2008.
105. Tsen KT, Tsen SWD, Hung CF, Wu TC, Kibler K, Jacob B, Kiang JG. Selective inactivation of human immunodeficiency virus with an ultrashort pulsed laser. Proc. of SPIE 7175: 717510-1 – 717510-8, 2009.
106. Kiang JG, Smith JA, and Agravante NG. Geldanamycin analog 17-DMAG inhibits iNOS and caspases in gamma irradiated human T cells. Radiat Res 172: 321-330, 2009.
107. Gorbunov NV, Kiang JG. Up-regulation of Autophagy in the Small Intestine Paneth Cell in Response to Total-Body γ-Irradiation. J Pathol 219: 242-252, 2009.
108. Jiao W, Kiang JG, Cary L, Elliott TB, Pellmar TC, Ledney GD. COX-2 inhibitors are contraindicated for therapy of combined injury. Radiat Res 172: 686-697, 2009.
109. Tsen KT, Tsen S-WD, Fu Q, Lindsay SM, Kibler K, Jacobs B, Wu TC, Karanam B, Jagu S, Roden RBS, Hung C-F, Sankey OF, Ramakrishna B, Kiang JG. Photonic approach to the selective inactivation of viruses with a near-infrared subpicosecond fiber laser. J Biomed Opt 14: 064042 (10 pages), 2009.
110. Kiang JG, Jiao W, Cary L, Mog SR, Elliott TB, Pellmar TC, Ledney GD. Wound trauma increases radiation-induced mortality by increasing iNOS, cytokine concentrations, and bacterial infections. Radiate Res 173: 319-332, 2010.
111. Kiang JG, Garrison BR, Gorbunov NV. Radiation combined injury: DNA damage, apoptosis, and autophagy. Adapt Med 2: 1-10, 2010. doi: 10.4247/AM.2010.ABA004.
112. Daly MJ, Gaidamakova EK, Matrosova VY, Kiang JG, Fukumoto R, Wehr NB, Viteri G, Berlett BS, Levine RL. Small molecule proteome-shield in Deinococcus radiodurans. PLoS One 5(9): e12570 (15 pages), 2010.
113. Gorbunov NV and Kiang JG. Activation of IL-1β pathway and augmentation of Paneth cell α-defensin-4 in small intestine following total-body γ-irradiation. Intl J Immunopathol Pharmacol 23: 1111-1123, 2010.
114. Kiang JG, Smith JA, Agravante NG, Gorbunov NV. Geldanamycin analog 17-DMAG has radioprotective activity in mice. Radiat Res, in review.
115. Fukumoto R, Kiang JG. Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat shock protein 90 kDa after ionizing radiation. Radiat Res 176: 333-345, 2011.
116. Kiang JG, Agravante NG, Smith JT, Bowman PD. 17-DMAG increases Bcl-2 and inhibits hemorrhage-induced increases in iNOS activation, caspase-3 activity and TNF-a. Cell & Bioscience 1: 21 (10 pages), 2011.
117. Tsen KT, Tsen SWD, Fu Q, Lindsay SM, Li Z, Yan H, Cope S, Vaiana S, Kiang JG. Studies of inactivation of encephalomyocaditis virus, M13 bacteriophage and Salmomella typhimurium by using a visible femtosecond laser irradiation: insight into the possible inactivation mechanisms. J Biomed Optics 16: 078003 (11 pages), 2011.
118. Whitnall MH, Cary LH, Moroni M, Ngudiankama BF, Landauer MR, Singh VK, Ghosh SP, Kulkarni S, Miller AC, Kiang JG, Srinivasan V, Xiao M. United States Armed Forces Radiobiology Research Institute countermeasures program and related policy questions. Proceedings,Hiroshima University, 2012.
119. Kiang JG, Garrison BR, Burns TM, Zhai M, Dews IC, Ney PH, Fukumoto R, Cary LH, Elliott TB, Ledney GD. Wound trauma alters ionizing radiation dose assessment. Cell Bioscience 2: 20 (12 pages), 2012.
120. Tsen S-W D, Wu TC, Kiang JG, Tsen KT. Prospects for a novel ultrashort pulsed laser technology for pathogen inactivation. J Biomed Sci 19: 62 (11 pages), 2012.
121. Kiang JG. Overview of biological effects of irradiation combined injury. NATO-HFM-223-P5:1-18, 2012.
122. Fukumoto R, Cary LH, Gorbunov NV, Elliott TB, Kiang JG. Ciprofloxacin modulates cytokine profiles, accelerates bone marrow recovery and mitigates ileum injury after radiation combined with wound trauma. PLoS One 8: e58389 (11 pages), 2013. doi: 10.1371/journal.pone.0058389. PMID: 23520506
123. Gorbunov NV, Garrison BR, McDaniel DP, Zhai M, Liao1 P-J, Nurmemet N, Kiang JG. Adaptive redox response of mesenchymal stromal cells to stimulation with lipopolysaccharide inflammagen: mechanisms of remodeling of tissue barriers in sepsis. Oxid Med Cell Longev 2013: 186795 (16 pages), 2013. doi: 10.1155/2013/186795. PMID: 23710283
124. Lu X, Nurmemet D, Bolduc DL, Elliott TB, Kiang JG. Radioprotective effects of oral 17-DMAG in mice: Bone marrow and small intestine. Cell Bioscience 3: 36 (16 pages), 2013. doi: 10.1186/2045-3701-3-36. PMID: 24499553
125. Kiang JG, Ledney GD. Skin injuries reduce survival and modulate corticosterone, C-reactive protein, complement component 3, IgM, and prostaglandin E2 after whole-body reactor-produced mixed field (n + γ-photons) irradiation. Oxid Med Cell Longev, 2013: 821541 (10 pages), 2013. doi: 10.1155/2013/821541. PMID: 24175013
126. Kiang JG, Garrison BR, Smith JT, Fukumoto R. Ciprofloxacin as a potential radio-sensitizer to tumor cells and a radioprotectant for normal cells: Differential effects on -H2AX formation, p53 phosphorylation, Bcl-2 production, and cell death. Cell Mol Biochem 393: 133-143, 2014. doi: 10.1007/s11010-014-2053-z. PMID: 24802382
127. Kiang JG, Fukumoto R. Ciprofloxacin increases survival after ionizing irradiation combined injury: gamma-H2AX formation, cytokine/chemokine, and red blood cells. Health Physics 106: 720-726, 2014. doi: 10.1097/HP.0000000000000108. PMID: 24776905
128. Fukumoto R, Burns TM, Kiang JG. Ciprofloxacin Enhances Stress Erythropoiesis in Spleen and Increases Survival after Whole-Body Irradiation Combined with Skin-Wound Trauma, PLoS One 9(2): e90448, 2014. doi: 10.1371/journal.pone.0090448. PMID: 24587369
129. Kiang JG, Zhai M, Liao P-J, Bolduc DL, Elliott TB, Gorbunov NV. Pegylated G-CSF inhibits blood cell depletion, increases platelets, blocks splenomegaly, and improves survival after whole-body ionizing irradiation but not after irradiation combined with burn. Oxid Med Cell Longev 2014: 481392 (10 pages), 2014. doi: 10.1155/2014/481392. PMID: 24738019
130. Kiang JG, Zhai M, Liao P-J, Elliott TB, Gorbunov NV. Ghrelin therapy improves survival after whole-body ionizing irradiation combined with wound or burn: Amelioration of leukocytopenia, thrombopenia, splenomegaly, and bone marrow injury. Oxid Med Cell Longev 2014: 215858, 2014. doi: 10.1155/2014/215858. PMID: 25374650
131. Gorbunov NV, Elliott TB, McDaniel DP, Zhai M, Liao P-J, Kiang JG. Mitophagy and mitochondrial remodeling in mouse mesenchymal stromal cells following a challenge with Staphylococcus epidermidis. J Cell Mol Med 19:1133-1150, 2015. doi: 10.1111/jcmm.12518. PMID: 25721260
132. Kiang JG, Gorbunov NV. Bone marrow mesenchymal stem cells increases survival after ionizing irradiation combined with wound trauma: Characterization and therapy. J Cell Sci Ther 5:190 (8 pages), 2014. doi: 10.4172/2157-7013.1000190
133. Elliott TB, Bolduc DL, Ledney GD, Kiang JG, Fatanmi OO, Wise S, Romaine PLP, Newman VL, Singh VK. Combined immunomodulator and antimicrobial therapy eliminates polymicrobial sepsis and modulates cytokine production in mice exposed to radiation and combined injury. Int J Radiat Biol 91(9):690-702, 2015. doi: 10.3109/09553002.2015.1054526. PMID: 25994812
134. Swift JM, Smith JT, Kiang JG. Ciprofloxacin therapy mitigates ATP loss after irradiation combined with wound trauma: Preservation of pyruvate dehydrogenase and inhibition of pyruvate dehydrogenase kinase 1. Radiat Res 183: 684-692, 2015. PMID: 26010714
135. Swift JM, Smith JT, Kiang JG. Hemorrhage Trauma Increases Radiation-Induced Trabecular
Bone Loss and Marrow Cell Depletion in Mice. Radiat Res 183: 578-583, 2015. doi: 10.1667/RR13960.1 PMID: 25897554
136. Swift JM, Swift SN, Smith JT, Kiang JG, Allen MR. Skin wound trauma, following high-dose radiation exposure, amplifies and prolongs skeletal tissue loss. Bone 81: 487-494, 2015. doi: 10.1016/j.bone.2015.08.022 PMID: 26335157
137. Islam A, Bolduc DL, Zhai M, Kiang JG, Swift JM. Daily Captopril Dosing Increases Survival after Whole-Body Ionizing Irradiation but Decreases Survival after in combination with Combined Burn Trauma in Mice. Radiat Res 184:273-279, 2015. doi: 10.1667/RR14113.1. PMID: 26305295
138. Kiang JG, Smith JT, Anderson MN, Swift JM, Gupta P, Balakathiresan N, Maheshwari RK. Hemorrhage exacerbates radiation effects on survival, leukocytopenia, thrombopenia, erythropenia, bone marrow cell depletion and hematopoiesis, and inflammation-associated microRNAs expression in kidney. PLoS ONE 10:e0139271, 2015. doi: 10.1371/journal.pone.0139271. PMID: 26422254
139. Klionsky DJ…Kiang JG…Zughaler SM. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12: 1-222, 2016. PMID: 26799652
140. Kiang JG. Adult mesenchymal stem cells and radiation injury. Health Phys 111:198-203, 2016. doi: 10.1097/HP.0000000000000459. PMID: 27356065
141. Gupta P, Gayen M, Smith JT, Matrosova VY, Gaidamakova EK, Daly MJ, Kiang JG, Maheshwari RK. MDP: A Deinococcus Mn2+-Decapeptide Complex Protects Mice from Ionizing Radiation. PLoS One 11: e0160575, 2016. doi: 10.1371/journal.pone.0160575. PMID: 27500529
142. Kiang JG. Exacerbation of mild hypoxia on acute radiation syndrome and subsequent mortality. Adaptive Med 9(1): 28-33, 2017. doi: 10.4247/AM.2017.ABG170
143. Kiang JG, Zhai M, Liao P.-J., Ho C, Gorbunov NV, Elliott TB. Thrombopoietin receptor agonist mitigate hematopoietic acute radiation syndrome and improves survival after whole-body ionizing irradiation followed by wound trauma. Mediators of Inflammation 2017:7582079, 2017. doi: 10.1155/2017/7582079 PMID: 28408792
144. Kiang JG, Zhai M, Bolduc DL, Smith JT, Anderson MN, Ho C, Lin B, Jiang S. Combined therapy of pegylated-G-CSF and Alx4100TPO improves survival and mitigate acute radiation syndrome after whole-body ionizing irradiation alone and followed by wound trauma. Radiat Res 188:476-490, 2017. doi: 10.1667/RR14647.1 PMID: 28850300
145. Kiang JG, Smith JT, Anderson MN, Elliott TB, Gupta P, Balakathiresan N, Maheshwari RK, Knollmann-Ritschel B. Hemorrhage enhances cytokine, complement component 3, and caspase-3, and regulates microRNAs associated with intestinal damage after whole-body gamma-irradiation in combined injury. PLoS ONE 12(9):e0184393, 2017. doi: 10.1371/journal.pone.0184393.PMID: 28934227
146. Gorbunov NV, Kiang JG. Ghrelin therapy decreases incidents of intracranial hemorrhage in mice after whole-body ionizing irradiation combined with burn trauma. Int J Mol Sci 18(8). pii: E1693, 2017. doi: 10.3390/ijms18081693. PMID: 28771181
147. Kiang JG, Smith JT, Hegge SR, Ossetrova N. Circulating cytokine/chemokine concentrations respond to ionizing radiation doses but not radiation dose rates: granulocyte-colony stimulating factor and interleukin-18. Radiat Res 189:634-643, 2018. Doi: 10.1667/RR14966.1 PMID: 29652619
148. Kiang JG, Anderson MN, Smith JT. Ghrelin therapy sustains granulocyte colony-stimulating factor and keratinocyte factor to mitigate hematopoietic syndrome and spleen after whole-body ionizing irradiation combined with wound. Cell Biosci 8:27, 2018. doi: 10.1186/s13578-018-0225-3 PMID: 29632660
149. Li X, Cui W, Hull L, Smith JT, Kiang JG, Xiao M. Effects of low-to-moderate doses of γ-radiation on mouse hematopoietic system. Radiat Res 190: 612-622, 2018. doi: 10.1667/RR15087.1. PMID: 30311842
150. Kiang JG, Olabisi AO. Radiation: A poly-traumatic hit leading to multi-organ death. Cell Biosci 9:25, 2019. doi: 10.1186/s13578-019-0286-y PMID: 30911370
151. Kiang JG, Smith JT, Anderson MN, Umali MV, Ho C, Zhai M, Lin B, Jiang S. A novel therapy, using Ghrelin with pegylated G-CSF, inhibits brain hemorrhage from ionizing radiation or combined radiation injury. Pharm Pharmacol Int J 7(3): 133-145, 2019. doi: 10.15406/ppij.2019.07.00243 PMCID: PMC8341084 PMID: 34368440
152. Kiang JG, Smith JT, Cannon G, Anderson MN, Ho C, Zhai M, Cui W, Xiao M. Ghrelin, a novel therapy, corrects cytokine and NF-κB-AKT-MAPK network and mitigates intestinal injury induced by combined radiation and skin-wound trauma. Cell Biosci 10:63, 2020. doi: 10.1186/s13578-020-00425-z PMID: 32426105 PMCID: PMC7216502
153. Gupta P, Sharma A, Smith JT, Anderson MN, Gaidamakova EK, Daly MJ, Kiang JG, Day R, Knollmann-Ritschel B. Prophylactic administration of Deinococcus manganese-decapeptide-phosphate complex or Mn(II) protects mice from lethal gamma radiation. PLoS ONE, the 2nd review, 2021.
154. Gorbunov NV, Kiang JG. Brain damage and patterns of neurovascular disorder after ionizing irradiation. Complications in radiotherapy and radiation combined injury. Radiat Res 196(1): 1-16, 2021. doi: 10.1667/RADE-20-00147.1. PMID: 33979447. (The figure used for the journal’s cover)
155. Wang L, Zhai M, Lin B, Cui W, Hull L, Li X, Anderson MN, Smith JT, Umali MV, Jiang S, Kiang JG, Xiao M. Peg-G-CSF and L-Citrulline combinational therapy for mitigating skin wound combined radiation injury in a mouse model. Radiat Res 196(1): 113-127, 2021, doi: 10.1667/RADE-20-00151.1. PMID: 33914884.
156. Kiang JG, Zhai M, Lin B, Smith JT, Anderson MN, Jiang S. Co-therapy of Pegylated-G-CSF and Ghrelin for enhancing survival after exposure to lethal radiation. Front Pharmacol 2021:628018, 2021. doi: 10.3389/fphar.2021.628018 PMID: 33603673
157. Bene BJ, Blakely WF, Burmeister DM, Cary L, Chhetri SJ, Davis CM, Ghosh SP, Holmes-Hampton GP, Iordanskiy S, Kalinich JF, Kiang JG, Kumar VP, Lowy RJ, Miller A, Naeem M, Schauer DA, Senchak L, Singh VK, Stewart AJ, Velazquez EM, Xiao M. Celebrating 60 Years of Accomplishments of the Armed Forces Radiobiology Research Institute. Radiat Res 196(2):129-146, 2021. doi: 10.1667/21-00064.1. Online ahead of print. PMID: 33979439.
158. Cannon G, Kiang JG. A review of the impact on the ecosystem after ionizing irradiation: wildlife population. Int J Radiat Biol 98(6):1054-1062, 2022. doi: 10.1080/09553002.2020.1793021. Online ahead of print. PMID: 32663058
159. Mothersill CE, Oughton DH, Schofield PN, Abend M, Adam-Guillermin C, Ariyoshi K, Beresford NA, Bonisoli-Alquati A, Cohen J, Dubrova Y, Geras'kin SA, Hevrøy TH, Higley KA, Horemans N, Jha AN, Kapustka LA, Kiang JG, Madas BG, Powathil G, Sarapultseva EI, Seymour CB, Vo NTK, Wood MD. From tangled banks to toxic bunnies; a reflection on the issues involved in developing an ecosystem approach for environmental radiation protection. Int J Radiat Bio 98(6):1185-1200, 2022. doi: 10.1080/09553002.2020.1793022 Online ahead of print. PMID: 32659186
160. Kiang JG, Cannon G, Olson MG, Smith JT, Anderson MN, Umali MV, Zhai M, Ho K, Ho C, Cui W, Xiao M. Female mice are more resistant to the mixed-fields (67% neutron+33% gamma) radiation-induced injury in bone marrow and GI than male mice due to sustained increases in G-CSF and the Bcl-2/Bax ratio, and lower miR-34a and MAPK activation. Radiat Res 198(2): 120-133, 2022. doi: 10.1667/RADE-21-00201.1. PMID: 35452510 PMCID: PMC9425239
161. Miller A, Kiang JG, Chhetri SJ, Bene BJ, Blakely WF. NATO report. 2022.
162. Barbee G, …Kiang JG …woodruff C. JOINT TRAUMA SYSTEM CLINICAL PRACTICE GUIDELINE Chemical, Biological, Radiological and Nuclear (CBRN) Injury Response Part III: Medical Management of Radiation Exposure and Nuclear Events. 2022.
163. Wang L, Lin B, Zhai M, Cui W, Hull L, Zizzo A, Li X, Kiang JG, Xiao M. Deteriorative effects of radiation injury combined with skin wounding in a mouse model. Toxins 10:785, 2022 doi:10.3390/toxics10120785
164. Kiang JG, Blakely WF. Radiation combined injury and its countermeasures and biodosimetry. Int J Radiat Bio, in review, 2022.

E-Book (1)
1. Gorbunov NV, Kiang JG. Autophagy-mediated innate defense mechanism in crypt cells responding to impairment of small intestine barrier after total-body gamma-photon irradiation. Cell Biology Research Progress, Nova Science Publishers, INC. Hauppauge, NY. ISBN: 978-1-62417-374-5 http://www.novapublishers.com, 2012.

Book chapters (11)
1. Yan X, Lu PY, and Kiang JG. Qigong: basic science studies in Biology. In: Healing, Intention, and Energy medicine Science, Research Methods and Clinical Implications. (Eds. WB Jonas and C Crawford) Churchill Livingstone, London, UK pp. 103-119, 2003.
2. Kiang JG and McClain DE. Heat stress. In: Combat Medicine Basic and Clinical Research in Military, Trauma, and Emergency Medicine (Eds. GC Tsokos and JL Atkins), Humana Press, New Jersey, pp. 83-101, 2003.
3. Kiang JG. Human bioenergy effects at the cellular and molecular level. In: Life and Mind In Search of Physical Basis (ed. S. Savva), Trafford Publishing, Victoria BC, Canada, pp. 117-137, 2007.
4. Tsen KT, Tsen SWD, Dykeman EC, Sankey OF, Kiang JG. Inactivation of viruses with femtosecond laser pulses. In: Contemporary Trends in Bacteriophage research (Ed: Horace T. Adams), Nova Science Publishers, NY, ISBN: 978-1-60692-181-4, pp. 151-177, 2009.
5. Kumar KS, Kiang JG, Whitnall MH, Hauer-Jensen M. Perspectives in radiological and nuclear countermeasures. In: Textbook of Military Medicine, pages 239-266, 2012.
6. Gorbunov NV, Kiang JG. Autophagy-mediated innate defense mechanism in crypt cells responding to impairment of small intestine barrier after total-body gamma-photon irradiation. In: Autophagy: Principles, Regulation and Roles in Disease (ed: Gorbunov NV), Nova Science Pulbishers, INC. Hauppauge, NY. 2012.
7. Gorbunov NV, Garrison BR, Zhai M, McDaniel DP, Ledney GD, Elliott TB, Kiang JG. Autophagy-mediated defense response of mouse mesenchymal stromal cells (MSCs) to challenge with Escherichia coli. In: Protein Interaction / Book 1; ISBN 979-953-307-577-7. Eds.: Cai J and Wang H. InTech Open Access Publisher; www.intechweb.org. pp. 23-44, 2012.
8. Kiang JG, Fukumoto R, Gorbunov NV. Lipid peroxidation after ionizing irradiation leads to apoptosis and autophagy. In: Lipid Peroxidation; ISBN 980-953-307-143-0. Eds.: Angel Catala, InTech Open Access Publisher: www.intechweb.org, Rijeka, Croatia. pp.261-278, 2012.
9. Gorbunov NV, Elliott TB, McDaniel DP, Lund K, Liao PJ, Zhai M, Kiang JG. Up-regulation of autophagy defense mechanisms in mouse mesenchymal stromal cells in response to ionizing irradiation followed by bacterial challenge. In: Autophagy, ISBN 980-953-307-971-9. Ed: Yannick Bailly, InTech Open Access Publisher: www.intechweb.org, Rijeka, Croatia. pp. 331-350, 2013.
10. Kiang JG. Characterization and therapeutic uses of adult mesenchymal stem cells. In: Stem Cell Toxicity and Medicine (ed. S.C. Sahu). Wiley & Sons, West Sussex, pp. 288-301, 2016.
11. Kiang JG. Mesenchymal Stem Cells and Exosomes in Tissue Regeneration and Remodeling: Characterization and Therapy. In: Tissue Barriers in disease, Injury and regeneration. (ed. Nikolai V. Gorbunov). Elsevier, Cambridge, MA pp. 159-185, 2022.

Career Highlights: Positions, Projects, Deployements, Awards and Additional Publications

Patent 1. Method of Inhibiting Inflammatory Response, Wei ET, and Kiang JG, U.S. Patent 4,801,612 (January 31, 1989)

Patent 2. System and method for diminishing the function of microorganisms with a visible femtosecond laser, Tsen KT, Tsen SWD, and Kiang JG, U.S. Patent 60,932,668 (June 1, 2007); South Africa Patent 2010/00380 (Sep 29. 2010); China Patent CN101971008B (May 15, 2012)

Patent 3. 17-DMAG as a radioprotectant, Kiang JG, U.S. Provisional Patent 61,122,041 (Dec 11, 2008)

The 2022 Radiobiology Research Award as Senior Principal Investigator, USUHS Research Days, 2022; Best Poster Award, Society of Chinese Bioscientists in America, 3-18-2017

2016 AFRRI Research Award, AFRRI, 2016

Research and Development Achievements Award, U.S. Department of Army, U.S. Department of Defense, 2006

DOD Female Science, Technology, Engineering, Mathematics Role Models, 2006

Order of Military Medical Merit, 2006

Outstanding Alumni Award 2005, Fu-Jen Catholic University, 2005

The 20th Century Award for Achievement in Life Sciences, International Biographical Centre of Cambridge, England, 2000

Representative Bibliography

Kiang JG, Cannon G, Olson MG, Smith JT, Anderson MN, Umali MV, Zhai M, Ho K, Ho C, Cui W, Xiao M. Female mice are more resistant to the mixed-fields (67% neutron+33% gamma) radiation-induced injury in bone marrow and GI than male mice due to sustained increases in G-CSF and the Bcl-2/Bax ratio, and lower miR-34a and MAPK activation. Radiat Res 198(2): 120-133, 2022. doi: 10.1667/RADE-21-00201.1. PMID: 35452510 PMCID: PMC9425239

Kiang JG, Zhai M, Lin B, Smith JT, Anderson MN, Jiang S. Co-therapy of Pegylated-G-CSF and Ghrelin for enhancing survival after exposure to lethal radiation. Front Pharmacol 2021:628018, 2021. doi: 10.3389/fphar.2021.628018 PMID: 33603673

Kiang JG, Smith JT, Cannon G, Anderson MN, Ho C, Zhai M, Cui W, Xiao M. Ghrelin, a novel therapy, corrects cytokine and NF-κB-AKT-MAPK network and mitigates intestinal injury induced by combined radiation and skin-wound trauma. Cell Biosci 10:63, 2020. doi: 10.1186/s13578-020-00425-z PMID: 32426105 PMCID: PMC7216502

Kiang JG, Smith JT, Anderson MN, Umali MV, Ho C, Zhai M, Lin B, Jiang S. A novel therapy, using Ghrelin with pegylated G-CSF, inhibits brain hemorrhage from ionizing radiation or combined radiation injury. Pharm Pharmacol Int J 7(3): 133-145, 2019. doi: 10.15406/ppij.2019.07.00243 PMCID: PMC8341084 PMID: 34368440

Kiang JG, Anderson MN, Smith JT. Ghrelin therapy sustains granulocyte colony-stimulating factor and keratinocyte factor to mitigate hematopoietic syndrome and spleen after whole-body ionizing irradiation combined with wound. Cell Biosci 8:27, 2018. doi: 10.1186/s13578-018-0225-3.

Gorbunov NV, Kiang JG. Ghrelin therapy decreases incidents of intracranial hemorrhage in mice after whole-body ionizing irradiation combined with burn trauma. Int J Mol Sci 18(8). pii: E1693, 2017. doi: 10.3390/ijms18081693. PMID: 28771181

Kiang JG, Smith JT, Anderson MN, Elliott TB, Gupta P, Balakathiresan N, Maheshwari RK, Knollmann-Ritschel B. Hemorrhage enhances cytokine, complement component 3, and caspase-3, and regulates microRNAs associated with intestinal damage after whole-body gamma-irradiation in combined injury. PLoS ONE 12(9):e0184393, 2017. doi: 10.1371/journal.pone.0184393.PMID: 28934227

Kiang JG, Smith JT, Anderson MN, Swift JM, Gupta P, Balakathiresan N, Maheshwari RK. Hemorrhage exacerbates radiation effects on survival, leukocytopenia, thrombopenia, erythropenia, bone marrow cell depletion and hematopoiesis, and inflammation-associated microRNAs expression in kidney. PLoS ONE 10:e0139271, 2015. doi: 10.1371/journal.pone.0139271. PMID: 26422254

Kiang JG, Gorbunov NV. Bone marrow mesenchymal stem cells increases survival after ionizing irradiation combined with wound trauma: Characterization and therapy. J Cell Sci Ther 5:190 (8 pages), 2014. doi: 10.4172/2157-7013.1000190

Kiang JG, Zhai M, Liao P-J, Elliott TB, Gorbunov NV. Ghrelin therapy improves survival after whole-body ionizing irradiation combined with wound or burn: Amelioration of leukocytopenia, thrombopenia, splenomegaly, and bone marrow injury. Oxid Med Cell Longev 2014: 215858, 2014. doi: 10.1155/2014/215858. PMID: 25374650