Thomas Darling M.D. Ph.D.

Education

1979-1983 B.S. in Biology, Houghton College, Houghton, NY
1983-1990 M.D.-Ph.D., Duke University School of Medicine, Duke University Graduate School, Department of Cell Biology, Durham, NC,
1990-1991 Medicine Internship, UNC Hospitals, Chapel Hill, NC
1991-1994 Dermatology Residency, Duke University Medical Center, Durham, NC
1994-1996 Clinical Associate, Dermatology Branch, NIH, Bethesda, MD
1996-1998 Clinical Fellow, Dermatology Branch, NIH, Bethesda, MD

Career Highlights: Positions, Projects, Deployements, Awards and Additional Publications

1999-2005 Assistant Professor of Dermatology, Assistant Professor of Anatomy Physiology and Genetics (secondary), Uniformed Services University of the Health Sciences

2005-2012 Associate Professor of Dermatology, (tenured 2005) Associate Professor of Anatomy Physiology and Genetics (secondary), Associate Professor of Molecular and Cell Biology (secondary), Uniformed Services University of the Health Sciences

2012-present Professor of Dermatology Professor of Anatomy Physiology and Genetics (secondary), Professor of Molecular and Cell Biology (secondary), Uniformed Services University of the Health Sciences

2014-present Chair of Dermatology Uniformed Services University of the Health Sciences, Bethesda, MD

1994-1998 United States Public Health Service, Research Officer Group, 0-3 (LT) Sr. Assistant Surgeon, promoted to Permanent Grade: 0-4 (LT Commander) Surgeon, Bethesda, MD

2009 James Leonard Award for Excellence in Clinical Research, USUHS

2012 Member of research team that received a National Human Genome Research Institute GREAT Award, for “Discovery of the cause of Proteus syndrome”

2013 Member, American Dermatological Association

2013 Member of research team that received a National Human Genome Research Institute GREAT Award, for “Defining a new class of human disease caused by somatic mutations in the PI3K-AKT1 pathway”

2016 Member of research team to receive a NHLBI Orloff Science Award for studies of circulating tumor cells in patients with LAM and TSC

Representative Bibliography

Klover PJ, Thangapazham RL, Kato J, Wang JA, Anderson SA, Hoffmann V, Steagall WK, Li S, McCart E, Nathan N, Bernstock JD, Wilkerson MD, Dalgard CL, Moss J, Darling TN. Tsc2 disruption in mesenchymal progenitors results in tumors with vascular anomalies overexpressing Lgals3. Elife. 2017;6. pii: e23202. PMID: 28695825

Treichel AM, Boeszoermenyi B, Lee CR, Moss J, Kwiatkowski DJ, Darling TN. Diagnosis of Mosaic Tuberous Sclerosis Complex Using Next-Generation Sequencing of Subtle or Unusual Cutaneous Findings. JID Innov. 2023 Jan 9;3(2):100180.

Cartron AM, Buccine D, Treichel AM, Lee CR, Moss J, Darling TN. Miliary fibromas in tuberous sclerosis complex. J Eur Acad Dermatol Venereol. 2021;35(5):1226-1229. PMID: 33565654.

Nathan N, Wang JA, Li S, Cowen EW, Haughey M, Moss J, Darling TN. Improvement of tuberous sclerosis complex (TSC) skin tumors during long-term treatment with oral sirolimus. J Am Acad Dermatol. 2015;73:802-8. PMID: 26365597

Teng JM, Cowen EW, Wataya-Kaneda M, Gosnell ES, Witman PM, Hebert AA, Mlynarczyk G, Soltani K, Darling TN. Dermatologic and dental aspects of the 2012 international tuberous sclerosis complex consensus statements. JAMA Dermatol. 2014;150:1095-101. PMID: 25029267

Thangapazham RL, Klover P, Li S, Wang JA, Sperling L, Darling TN. A model system to analyze the ability of human keratinocytes to form hair follicles. Exp Dermatol. 2014;23:443-6. PMID: 24758480

Tyburczy ME, Wang JA, Li S, Thangapazham R, Chekaluk Y, Moss J, Kwiatkowski DJ, Darling TN. Sun exposure causes somatic second-hit mutations and angiofibroma development in tuberous sclerosis complex. Hum Mol Genet. 2014;23:2023-9. PMID: 24271014

Klonowska K, Giannikou K, Grevelink JM, Boeszoermenyi B, Thorner AR, Herbert ZT, Afrin A, Treichel AM, Hamieh L, Kotulska K, Jozwiak S, Moss J, Darling TN, Kwiatkowski DJ. Comprehensive genetic and phenotype analysis of 95 individuals with mosaic tuberous sclerosis complex. Am J Hum Genet. 2023;110(6):979-988.